What is the sum of real roots of the equation
(x+1)(x+41)(x+21)(x+43)=3245?<spanclass=′latex−bold′>(A)</span>0<spanclass=′latex−bold′>(B)</span>−1<spanclass=′latex−bold′>(C)</span>−23<spanclass=′latex−bold′>(D)</span>−45<spanclass=′latex−bold′>(E)</span>−127